Development and validation of nomograms for predicting overall and breast cancer-specific survival among patients with triple-negative breast cancer.

ABSTRACT:

Purpose

TNBC is generally more aggressive than other BC subtypes and has limited therapeutic options. We aimed to construct comprehensive and reliable nomograms to predict the OS and BCSS of TNBC patients to offer clinicians therapeutic guidance for improving the prognosis of TNBC patients.

Patients and methods

We used the SEER 19 Cancer Registry to identify 21,419 eligible TNBC patients diagnosed from January 1, 2010 to December 31, 2015, and divided the database randomly into a training cohort (n=10,709) and a validation cohort (n=10,710). The log-rank test and Cox analysis together with a competing risk model were utilized to identify independent prognostic factors for OS and BCSS, which were then integrated to construct nomograms.

Results

According to the training

SUBMITTER: Guo LW 

PROVIDER: S-EPMC6250111 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature