The sacrificial inactivation of the blue-light photosensor cryptochrome from Drosophila melanogaster.

ABSTRACT: Drosophila melanogaster cryptochrome functions as the primary blue-light receptor that mediates circadian photo entrainment. Absorption of a photon leads to reduction of the protein-bound FAD via consecutive electron transfer along a conserved tryptophan tetrad resembling the signalling state required for conformational changes and induction of subsequent signalling cascades. However, how the initial photochemistry and subsequent dark processes leading to downstream signalling are linked to each other at the molecular level is still poorly understood. Here, we investigated in detail the initial photochemical events in DmCRY by time-resolved and stationary absorption spectroscopy combined with quantum chemical and molecular dynamics calculations. We resolved the early events along the conse

SUBMITTER: Kutta RJ 

PROVIDER: S-EPMC6250122 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature