Vitamin D to Prevent Lung Injury Following Esophagectomy-A Randomized, Placebo-Controlled Trial.

ABSTRACT:

Objectives

Observational studies suggest an association between vitamin D deficiency and adverse outcomes of critical illness and identify it as a potential risk factor for the development of lung injury. To determine whether preoperative administration of oral high-dose cholecalciferol ameliorates early acute lung injury postoperatively in adults undergoing elective esophagectomy.

Design

A double-blind, randomized, placebo-controlled trial.

Setting

Three large U.K. university hospitals.

Patients

Seventy-nine adult patients undergoing elective esophagectomy were randomized.

Interventions

A single oral preoperative (3-14 d) dose of 7.5 mg (300,000 IU; 15 mL) cholecalciferol or matched placebo.

Measurements and main results

Primary outcome was chang

SUBMITTER: Parekh D 

PROVIDER: S-EPMC6250246 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature