High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy.

ABSTRACT:

Background

Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established on ART.

Methods

HIV-infected children aged 6-16 years, on ART at least 6 months were enrolled into a cross-sectional study from a public-sector paediatric HIV clinic in Harare, Zimbabwe. A standardized examination including transthoracic echocardiography was performed. Local echocardiographic reference ranges were used to define cardiac abnormalities. Logistic regression was used

SUBMITTER: Majonga ED 

PROVIDER: S-EPMC6250247 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature