A Microbial Signature of Psychological Distress in Irritable Bowel Syndrome.

ABSTRACT:

Objective

Irritable bowel syndrome (IBS) is associated with alterations along the brain-gut-microbiota axis. Previous studies have suggested a parallel segregation of microbial features and psychological burden in IBS. This study aimed at exploring the microbial correlates of psychological distress in patients with IBS.

Methods

Forty-eight patients with IBS (Rome III criteria, M (SD) age = 42 (15) years, 35 female, 25 diarrhea-dominant, 5 constipation-dominant, and 18 alternating-type IBS) were assessed for psychological and clinical variables with validated questionnaires, fecal samples underwent microbial 16S rRNA analyses (regions V1-2). Microbial analyses comprised examination of alpha and beta diversity, correlational analyses of bacterial abundance and comparisons amon

SUBMITTER: Peter J 

PROVIDER: S-EPMC6250280 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature