Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories.

ABSTRACT: Food aversions develop when the taste of a novel food is associated with sickness, which often occurs after food poisoning or chemotherapy treatment. We identified calcitonin-gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) as sufficient and necessary for establishing a conditioned taste aversion (CTA). Photoactivating projections from CGRP^PBN neurons to either the central nucleus of the amygdala or the bed nucleus of the stria terminalis can also induce robust CTA. CGRP^PBN neurons undergo plasticity following CTA, and inactivation of either Arc or Grin1 (genes involved in memory consolidation) prevents establishment of a strong CTA. Calcium imaging reveals that the novel food re-activates CGRP^PBN neurons after conditioning. Inhibition

SUBMITTER: Chen JY 

PROVIDER: S-EPMC6250580 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature