A scar-like lesion is apparent in basement membrane after wound repair in vivo.

ABSTRACT: Basement membrane is a highly conserved sheet-like extracellular matrix in animals, underlying simple and complex epithelia, and wrapping around tissues like muscles and nerves. Like the tissues they support, basement membranes become damaged by environmental insults. Although it is clear that basement membranes are repaired after damage, virtually nothing is known about this process. For example, it is not known how repaired basement membranes compare to undamaged ones, whether basement membrane components are necessary for epithelial wound closure, or whether there is a hierarchy of assembly that repairing basement membranes follow, similar to the hierarchy of assembly of embryonic basement membranes. In this report, we address these questions using the basement membrane of the Drosophil

SUBMITTER: Ramos-Lewis W 

PROVIDER: S-EPMC6250587 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature