Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs.

ABSTRACT:

Background

Transcriptional differences between heterogeneous stock mice and high drinking-in-the-dark selected mouse lines have previously been described based on microarray technology coupled with network-based analysis. The network changes were reproducible in 2 independent selections and largely confined to 2 distinct network modules; in contrast, differential expression appeared more specific to each selected line. This study extends these results by utilizing RNA-Seq technology, allowing evaluation of the relationship between genetic risk and transcription of noncoding RNA (ncRNA); we additionally evaluate sex-specific transcriptional effects of selection.

Methods

Naïve mice (N = 24/group and sex) were utilized for gene expression analysis in the ventral striatum; the t

SUBMITTER: Iancu OD 

PROVIDER: S-EPMC6250599 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature