T-Cell Clustering in Neoplastic Follicles of Follicular Lymphoma.

ABSTRACT: The nonneoplastic microenvironment is abundant in follicular lymphoma. Its composition has been reported to be associated with the course of the disease. Lack of animal models hampers studies of interaction between lymphoma and bystander cells. We aimed to identify indicators of cellular interaction exemplified by nonrandom distribution of cell types within neoplastic follicles. Physiological germinal centers and follicles in follicular lymphoma were stained to identify macrophages, all T, follicular T-helper, dendritic and B cells. Density of cell types and cell distribution (spatial point pattern) were analyzed by digital image analysis. The density of all T, follicular T-helper and dendritic cells was higher in the dark zone than in the light zone of physiological germinal centers. Dens

SUBMITTER: Schnotalle P 

PROVIDER: S-EPMC6250612 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature