Indoxyl Sulphate is Associated with Atrial Fibrillation Recurrence after Catheter Ablation.

ABSTRACT: Renal dysfunction results in the accumulation of various uremic toxins, including indoxyl sulphate (IS), and is a major risk factor for atrial fibrillation (AF). Experimental studies have demonstrated that IS exacerbates atrial remodelling via oxidative stress, inflammation, and fibrosis. However, its clinical impact on AF-promoting cardiac remodelling has not been described. Therefore, the purpose of this study was to clarify the relationship between basal IS levels and the 1-year outcomes after catheter ablation for the treatment of AF. Our prospective observational study included data from 125 patients with AF who underwent catheter ablation. Over a 1-year follow-up period, AF recurrence was identified in 21 patients. The 1-year AF-free survival was significantly lower in patients with

SUBMITTER: Yamagami F 

PROVIDER: S-EPMC6250674 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature