An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming.

ABSTRACT: Worldwide over 5 million children have been conceived using assisted reproductive technology, and research has concentrated on increasing the likelihood of ongoing pregnancy. However, studies using animal models have indicated undesirable effects of in vitro embryo culture on offspring development and health. In vivo, the oviduct hosts a period in which the early embryo undergoes complete reprogramming of its (epi)genome in preparation for the reacquisition of (epi)genetic marks. We designed an oviduct-on-a-chip platform to better investigate the mechanisms related to (epi)genetic reprogramming and the degree to which they differ between in vitro and in vivo embryos. The device supports more physiological (in vivo-like) zygote genetic reprogramming than conventional IVF. This approach will

SUBMITTER: Ferraz MAMM 

PROVIDER: S-EPMC6250703 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature