Functional Heterogeneity of CD4⁺ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC.

ABSTRACT: Resident memory T cells (T_RM) inhabit peripheral tissues and are critical for protection against localized infections. Recently, it has become evident that CD103⁺ T_RM are not only important in combating secondary infections, but also for the elimination of tumor cells. In several solid cancers, intratumoral CD103⁺CD8⁺ tumor infiltrating lymphocytes (TILs), with T_RM properties, are a positive prognostic marker. To better understand the role of T_RM in tumors, we performed a detailed characterization of CD8⁺ and CD4⁺ TIL phenotype and functional properties in non-small cell lung cancer (NSCLC). Frequencies of CD8⁺ and CD4⁺ T cell infiltrates in tumors were comparable, but w

SUBMITTER: Oja AE 

PROVIDER: S-EPMC6250821 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature