Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia.

ABSTRACT: Influenza and other respiratory viral infections are the most common type of acute respiratory infection. Viral infections predispose patients to secondary bacterial infections, which often have a more severe clinical course. The mechanisms underlying post-viral bacterial infections are complex, and include multifactorial processes mediated by interactions between viruses, bacteria, and the host immune system. Studies over the past 15 years have demonstrated that unique microbial communities reside on the mucosal surfaces of the gastrointestinal tract and the respiratory tract, which have both direct and indirect effects on host defense against viral infections. In addition, antiviral immune responses induced by acute respiratory infections such as influenza are associated with changes in

SUBMITTER: Hanada S 

PROVIDER: S-EPMC6250824 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature