Statin use and risk of contralateral breast cancer: a nationwide cohort study.

ABSTRACT:

Background

Statins have demonstrated antineoplastic effects in breast cancer cell lines, particularly in oestrogen receptor (ER)-negative cell lines. However, epidemiological studies have not supported a preventive effect of statin use against breast cancer. Therefore, we examined the association between statin use and contralateral breast cancer (CBC) risk among women with breast cancer.

Methods

We identified 52,723 women with non-metastatic breast cancer during 1996-2012 from the Danish Breast Cancer Group database. We defined time-varying post-diagnosis statin use as minimum two prescriptions lagged by 1 year. Cox regression analyses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for CBC associated with statin use.

Results

Statin use w

SUBMITTER: Langballe R 

PROVIDER: S-EPMC6251024 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature