Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer.

ABSTRACT:

Background

Currently delivered light dose (J/cm²) is the principal parameter guiding interstitial photodynamic therapy (I-PDT) of refractory locally advanced cancer. The aim of this study was to investigate the impact of light dose rate (irradiance, mW/cm²) and associated heating on tumour response and cure.

Methods

Finite-element modeling was used to compute intratumoural irradiance and dose to guide Photofrin^® I-PDT in locally advanced SCCVII in C3H mice and large VX2 neck tumours in New Zealand White rabbits. Light-induced tissue heating in mice was studied with real-time magnetic resonance thermometry.

Results

In the mouse model, cure rates of 70-90% were obtained with I-PDT using 8.4-245 mW/cm² and ≥45 J/cm²

SUBMITTER: Shafirstein G 

PROVIDER: S-EPMC6251027 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature