Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers.

ABSTRACT:

Background

Colorectal cancer (CRC) is a heterogeneous disease with distinct clinical subsets based on underlying genetic and epigenetic changes. DNA hypermethylation yields a unique CRC subset with a distinct phenotype and clinical behaviour, but this oncogenic pathway is not fully characterised. This study identifies and characterises miR-1247 as a novel tumour suppressor microRNA in methylated human colon cancers.

Method

Tumour samples from patients with hypermethylated and non-methylated colon cancer and cell lines were evaluated for miR-1247 expression and function. A murine subcutaneous xenograft model was used for in vivo functional studies.

Results

miR-1247 was methylated and underexpressed in methylator colon cancers. Overexpression of miR-1247 significantly i

SUBMITTER: Liang J 

PROVIDER: S-EPMC6251029 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature