Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis.

ABSTRACT:

Background

Premalignant breast lesions pose variable risks for transformation, raising the question who should receive treatment to counteract the potential progression to breast cancer. Because the secreted metastasis mediator Osteopontin (OPN) is a marker for breast cancer aggressiveness, its presence in these lesions may reflect progression risk.

Methods

By immunohistochemistry, we analyse the association of Osteopontin variant expression in healthy breasts, hyperplasias, papillomas, and carcinomas in situ from 434 women to assess a) staining for OPN exon 4 (present in OPN-a and OPN-b) or OPN-c in low-risk to high-risk lesions b) correlations between staining and progression (DCIS with invasion, invasive cancer) or survival.

Results

The markers correlate with risk,

SUBMITTER: Walaszek K 

PROVIDER: S-EPMC6251032 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature