Programmed Cell Death after Intracerebral Hemorrhage.

ABSTRACT:

Background

Intracerebral hemorrhage (ICH) accounts for up to 15% of all strokes and is characterized by high rates of mortality and morbidity. The post-ICH brain injury can be distinguished in 1) primary, which are caused by disruption and mechanical deformation of brain tissue due to hematoma growth and 2) secondary, which are induced by microglia activation, mitochondrial dysfunction, neurotransmitter and inflammatory mediator release. Although these events typically lead to necrosis, the occurrence of programmed cell death has also been reported after ICH.

Methods

We reviewed recent publications describing advance in pre- and clinic ICH research.

Results

At present, treatment of ICH patients is based on oral anticoagulant reversal, management of blood pressure and

SUBMITTER: Bobinger T 

PROVIDER: S-EPMC6251052 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature