Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.

ABSTRACT:

Background

Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer cells in the same microenvironment appear not to be affected. Mechanisms whereby cancer cells resist accelerated tryptophan degradation are not completely understood. We hypothesize that cancer cells co-opt IMPACT (the product of IMPrinted and AnCienT gene), to withstand periods of tryptophan deficiency.

Methods

A range of bioinformatic techniques including correlation and gene set variation analyses was applied to genomic datasets of cancer (The Cancer Genome Atlas) and normal (Genotype Tissue Expression Project) tissues to investigate IMPACT's role in cance

SUBMITTER: Tomek P 

PROVIDER: S-EPMC6251197 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature