Structural Brain Correlates of Attention Dysfunction in Lewy Body Dementias and Alzheimer's Disease.

ABSTRACT: Lewy body dementia (LBD) and Alzheimer's disease (AD) are common forms of dementia that have different clinical profiles but are both commonly associated with attentional deficits. The aim of this study was to investigate efficiency of different attentional systems in LBD and AD and its association with brain structural abnormalities. We studied reaction time (RT) data from 45 LBD, 31 AD patients and 22 healthy controls (HCs) using the Attention Network Test (ANT) to assess the efficiency of three different attentional systems: alerting, orienting and executive conflict. Voxel-based morphometry (VBM) was used to investigate relations between different attention components and cortical volume. Both dementia groups showed slower overall RTs than controls, with additional slowing in LBD relat

SUBMITTER: Cromarty RA 

PROVIDER: S-EPMC6251343 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature