Oncolytic myxoma virus synergizes with standard of care for treatment of glioblastoma multiforme.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is an aggressive form of brain cancer which is associated with poor prognosis. A variety of oncolytic viruses have previously shown positive efficacy against GBM, potentially offering new treatment options for patients. One such oncolytic virus is Myxoma virus (MYXV), a rabbit-specific poxvirus that has been shown to be efficacious against a variety of tumor models including GBM.

Purpose

The purpose of this study was to test the efficacy of MYXV combined with current treatment regimens for GBM in both established cell lines as well as patient biopsy samples.

Materials and methods

U118 gliobastoma cell lines were treated under various standard of care combinations (untreated, radiation and chemotherapeutic) prior to infection wi

SUBMITTER: Burton C 

PROVIDER: S-EPMC6251439 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature