Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment.

ABSTRACT:

Purpose

Zinc phthalocyanine (ZnPc) has been applied widely in photodynamic therapy (PDT) with high ROS-production capacity and intense absorption in the near-infrared region. However, weak tumor targeting and the aggregation tendency of ZnPc seriously affect the therapeutic effect of PDT. Therefore, overcoming the aggregation of ZnPc and enhancing its antitumor effect were the purpose of this study.

Methods

In this study, we first found that the aggregation behaviors of the photosensitizer ZnPc(TAP)₄, ZnPc substituted by tertiary amine groups, were regulated finely by pH and that ZnPc(TAP)₄ could be disaggregated gradually as the pH descended. ZnPc(TAP)₄ and human serum albumin (HSA) molecules were assembled into nanoparticles (NPs) for tumor

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6251464 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature