The Genomic Basis of Tumor Regression in Tasmanian Devils (Sarcophilus harrisii).

ABSTRACT: Understanding the genetic basis of disease-related phenotypes, such as cancer susceptibility, is crucial for the advancement of personalized medicine. Although most cancers are somatic in origin, a small number of transmissible cancers have been documented. Two such cancers have emerged in the Tasmanian devil (Sarcophilus harrisii) and now threaten the species with extinction. Recently, cases of natural tumor regression in Tasmanian devils infected with the clonally contagious cancer have been detected. We used whole-genome sequencing and FST-based approaches to identify the genetic basis of tumor regression by comparing the genomes of seven individuals that underwent tumor regression with those of three infected individuals that did not. We found three highly differentiated candidate geno

SUBMITTER: Margres MJ 

PROVIDER: S-EPMC6251476 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature