International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors.

ABSTRACT:

Objective

To provide outcome data concerning pregnancies exposed to the Interleukin-1 (IL-1) inhibitors prior to conception in both men and women, during pregnancy and breast feeding.

Methods

Retrospective data were collected from members of the International Society for Systemic Autoinflammatory diseases and collated in a single centre. A uniform data collection sheet was used to obtain standardized data including maternal age and diagnosis, type, duration of and response to IL-1 blockade, pregnancy duration, delivery, mode of feeding and neonatal development.

Results

There were 31 maternal-exposed pregnancies from seven countries and we report the first data on paternal exposure: six to anakinra and five to canakinumab, with no negative outcomes. We also report the

SUBMITTER: Youngstein T 

PROVIDER: S-EPMC6251516 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature