Effects of an autoinducer analogue on antibiotic tolerance in Pseudomonas aeruginosa.

ABSTRACT:

Objectives

Antibiotic tolerance causes chronic, refractory and persistent infections. In order to advance the development of a new type of drug for the treatment of infectious diseases, we herein investigated the effects of a newly synthesized analogue of the Pseudomonas aeruginosa quorum-sensing autoinducer named AIA-1 ( a uto i nducer a nalogue) on antibiotic tolerance in P. aeruginosa .

Methods

A P. aeruginosa luminescent strain derived from PAO1 was injected into neutropenic ICR mice and bioluminescence images were acquired for a period of time after treatments with antibiotics and AIA-1. In vitro susceptibility testing and killing assays for the planktonic and biofilm cells of PAO1 were performed using antibiotics and AIA-1. The expression of quorum-sensing-related gene

SUBMITTER: Amoh T 

PROVIDER: S-EPMC6251570 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature