Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study.

ABSTRACT:

Aims

A high visit-to-visit variability in cholesterol levels has been suggested to be an independent predictor of major adverse cardiovascular events in patients with coronary artery disease (CAD). Because whether this notion applies to general population is not known, we aimed to investigate the associations between total cholesterol (TC) variability and the risk of all-cause mortality, myocardial infarction (MI), and stroke.

Methods and results

We identified 3 656 648 subjects without a history of MI and stroke who underwent ≥3 health examinations from 2002 to 2007 in the Korean National Health Insurance System cohort. Total cholesterol variability was measured using the coefficient of variation (CV), standard deviation (SD), and variability independent of the mean (VIM).

SUBMITTER: Kim MK 

PROVIDER: S-EPMC6251576 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature