Plasma Transfusion Demystified: A Review of the Key Factors Influencing the Response to Plasma Transfusion.

ABSTRACT: Many studies have suggested that inappropriate plasma usage is common. An important factor contributing to futile plasma administration in most patients is the nonlinear relationship between coagulation-factor levels and the volume of plasma transfused. In this review, a validated mathematical model and data from the literature will be used to illuminate 3 key properties of plasma transfusion. Those properties are as follows: the effect of plasma transfusion on international normalized ratio (INR) is transient; for the same volume of transfused plasma, a greater reduction in INR is observed at higher initial INRs; and the effect of plasma transfusion on INR correction (ie, the difference between initial and final INRs) diminishes as more plasma is transfused. Frequent misunderstanding of t

SUBMITTER: Bryan AW 

PROVIDER: S-EPMC6251590 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature