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Neurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing.

ABSTRACT: A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next- generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome.

SUBMITTER: Mongkolrattanothai K 

PROVIDER: S-EPMC6251619 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Neurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing.

Mongkolrattanothai Kanokporn K   Naccache Samia N SN   Bender Jeffrey M JM   Samayoa Erik E   Pham Elizabeth E   Yu Guixia G   Dien Bard Jennifer J   Miller Steve S   Aldrovandi Grace G   Chiu Charles Y CY  

Journal of the Pediatric Infectious Diseases Society 20171101 4

A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next- generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome. ...[more]

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