Arginine Metabolism Is Altered in Adults with A-β + Ketosis-Prone Diabetes.

ABSTRACT: Background:A-β + ketosis-prone diabetes (KPD) is a subset of type 2 diabetes in which patients have severe but reversible β cell dysfunction of unknown etiology. Plasma metabolomic analysis indicates that abnormal arginine metabolism may be involved. Objective:The objective of this study was to determine the relation between gut microbiome and arginine metabolism and the relation between arginine availability and β cell function in KPD patients compared with control participants. Methods:Kinetics of arginine and related metabolites were measured with stable isotope tracers, and insulin secretory responses to arginine and glucose were determined under euglycemic and hyperglycemic conditions in 6 KPD patients and 6 age-, gender-, and body mass index-matched control participants. Glucose pote

SUBMITTER: Mulukutla SN 

PROVIDER: S-EPMC6251649 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature