TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis.

ABSTRACT:

Aims

The recent failures of HDL-raising therapies have underscored our incomplete understanding of HDL biology. Therefore there is an urgent need to comprehensively investigate HDL metabolism to enable the development of effective HDL-centric therapies. To identify novel regulators of HDL metabolism, we performed a joint analysis of human genetic, transcriptomic, and plasma HDL-cholesterol (HDL-C) concentration data and identified a novel association between trafficking protein, kinesin binding 2 (TRAK2) and HDL-C concentration. Here we characterize the molecular basis of the novel association between TRAK2 and HDL-cholesterol concentration.

Methods and results

Analysis of lymphocyte transcriptomic data together with plasma HDL from the San Antonio Family Heart Study (n = 12

SUBMITTER: Lake NJ 

PROVIDER: S-EPMC6251650 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature