Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies.

ABSTRACT: Sleep-wake disturbances following traumatic brain injury (TBI) are increasingly recognized as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep-wake disturbances can persist for years, often impairing quality of life. Recently, there has been a nearly exponential increase in the number of primary research articles published on the pathophysiology and mechanisms underlying sleep-wake disturbances after TBI, both in animal models and in humans, including in the pediatric population. In this review, we summarize over 200 articles on the topic, most of which were identified objectively using reproducible online search terms in PubMed. Although these studies differ in terms of methodology and detailed outcomes; overall, recent research describes a common

SUBMITTER: Sandsmark DK 

PROVIDER: S-EPMC6251652 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature