Klotho suppresses the renin-angiotensin system in adriamycin nephropathy.

ABSTRACT:

Backgrounds

Klotho protein interacts with the transforming growth factor β (TGF-β) receptor and Wnt, which contribute to the progression of renal disease, inhibiting their signals. Renal and circulating klotho levels are diminished in chronic kidney disease.

Methods

Experiments were performed to assess whether supplementation of klotho protein could have protective effects on the kidney. Rats were injected with adriamycin (5 mg/kg) and divided into three groups: those treated with vehicle, those treated with klotho protein and those treated with klotho plus 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD). Rats without adriamycin treatment were used as a control.

Results

Adriamycin reduced the serum klotho concentration and renal expression of klotho and E-cad

SUBMITTER: Takenaka T 

PROVIDER: S-EPMC6251653 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature