Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota.

ABSTRACT:

Background

trans-10,cis-12 Conjugated linoleic acid (t10,c12-CLA) is a dietary supplement that promotes weight loss by increasing fat oxidation and energy expenditure. We previously reported that in the absence of t10,c12-CLA, mice forced to lose equivalent body weight by food restriction (FR) do not exhibit increases in fat oxidation or energy expenditure but have improved glucose metabolism, consistent with FR as a metabolically healthy weight-loss method.

Objective

Because diet is a primary determinant of gut bacterial populations, we hypothesized that the disparate metabolic effects accompanying weight loss from t10,c12-CLA or FR could be related to altered intestinal microbiota.

Methods

Ten-week-old male LDL receptor-deficient (Ldlr-/-) mice were fed a high-fat,

SUBMITTER: den Hartigh LJ 

PROVIDER: S-EPMC6251681 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature