Enabling phenotypic big data with PheNorm.

ABSTRACT:

Objective

Electronic health record (EHR)-based phenotyping infers whether a patient has a disease based on the information in his or her EHR. A human-annotated training set with gold-standard disease status labels is usually required to build an algorithm for phenotyping based on a set of predictive features. The time intensiveness of annotation and feature curation severely limits the ability to achieve high-throughput phenotyping. While previous studies have successfully automated feature curation, annotation remains a major bottleneck. In this paper, we present PheNorm, a phenotyping algorithm that does not require expert-labeled samples for training.

Methods

The most predictive features, such as the number of International Classification of Diseases, Ninth Revision, Clin

SUBMITTER: Yu S 

PROVIDER: S-EPMC6251688 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature