Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer.

ABSTRACT:

Study question

Is supraphysiologic estradiol (E2) an independent predictor of low birth weight (LBW) in singletons born after fresh IVF-embryo transfer (ET) cycles?

Summary answer

Our results suggest that E2 > 2500 pg/ml is an independent predictor for LBW in full-term singletons born to normal responder patients undergoing fresh IVF-ET cycles.

What is known already

The pathogenesis of LBW in IVF singletons remains unknown. However, recent studies have suggested that the hyperestrogenic milieu generated during ovarian stimulation may create a sub-optimal peri-implantation environment, leading to placental dysfunction, and therefore, LBW.

Study design, size, duration

Retrospective cohort study of normal responder patients, <40 years old, undergoing fresh IVF-ET

SUBMITTER: Pereira N 

PROVIDER: S-EPMC6251696 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature