Resting zone of the growth plate houses a unique class of skeletal stem cells.

ABSTRACT: Skeletal stem cells regulate bone growth and homeostasis by generating diverse cell types, including chondrocytes, osteoblasts and marrow stromal cells. The emerging concept postulates that there exists a distinct type of skeletal stem cell that is closely associated with the growth plate^1-4, which is a type of cartilaginous tissue that has critical roles in bone elongation⁵. The resting zone maintains the growth plate by expressing parathyroid hormone-related protein (PTHrP), which interacts with Indian hedgehog (Ihh) that is released from the hypertrophic zone^6-10, and provides a source of other chondrocytes¹¹. However, the identity of skeletal stem cells and how they are maintained in the growth plate are unknown. Here we show, in a mouse mode

SUBMITTER: Mizuhashi K 

PROVIDER: S-EPMC6251707 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature