Immune Marker Profiling and Programmed Death Ligand 1 Expression Across NSCLC Mutations.

ABSTRACT:

Introduction

Programmed death 1/programmed death ligand 1 (PD-L1) axis inhibitors have been proven effective, especially in patients with tumors expressing PD-L1. Their clinical efficacy in patients with EGFR-activating mutations is still unclear, whereas KRAS mutations seem to be associated with good response.

Methods

We used multiplexed quantitative immunofluorescence to investigate PD-L1 expression and to characterize tumor infiltrating lymphocyte (TIL) populations and their activation status in more than 150 NSCLC patients with known mutation status.

Results

PD-L1 expression was significantly lower in EGFR-mutant compared to KRAS-mutant, and EGFR/KRAS wild-type (WT) tumors. KRAS mutant tumors were more inflamed with higher CD4+, CD8+ and CD20+ TILs. Subgroup analy

SUBMITTER: Toki MI 

PROVIDER: S-EPMC6251746 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature