Comparison of longitudinal Aβ in nondemented elderly and Down syndrome.

ABSTRACT: Down syndrome (DS) predisposes individuals to early Alzheimer's disease (AD). Using Pittsburgh Compound B ([¹¹C]PiB), a pattern of striatal amyloid beta (Aβ) that is elevated relative to neocortical binding has been reported, similar to that of nondemented autosomal dominant AD mutation carriers. However, it is not known whether changes in striatal and neocortical [¹¹C]PiB retention differ over time in a nondemented DS population when compared to changes in a nondemented elderly (NDE) population. The purpose of this work was to assess longitudinal changes in trajectories of Aβ in a nondemented DS compared to an NDE cohort. The regional trajectories for anterior ventral striatum (AVS), frontal cortex, and precuneus [¹¹C]PiB retention were explored over time

SUBMITTER: Tudorascu DL 

PROVIDER: S-EPMC6251757 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature