Quantification of Pulsed Operation of Rotary Left Ventricular Assist Devices with Wave Intensity Analysis.

ABSTRACT: The current generation of left ventricular assist devices (LVADs) provides continuous flow and has the capacity to reduce aortic pulsatility, which may be related to a range of complications associated with these devices. Pulsed LVAD operation using speed modulation presents a mechanism to restore aortic pulsatility and potentially mitigate complications. We sought to investigate the interaction of axial and centrifugal LVADs with the LV and quantify the effects of continuous and pulsed LVAD operations on LV generated wave patterns under different physiologic conditions using wave intensity analysis (WIA) method. The axial LVAD created greater wave intensity associated with LV relaxation. In both LVADs, there were only minor and variable differences between the continuous and pulsed operat

SUBMITTER: Bouwmeester JC 

PROVIDER: S-EPMC6251778 | biostudies-literature | 2019 May/Jun

REPOSITORIES: biostudies-literature