Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands.

ABSTRACT: Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. In experimentally infected non-human primates (NHPs) measles virus (MV) infects and depletes pre-existing memory lymphocytes, causing immune amnesia. A measles outbreak in the Dutch Orthodox Protestant community provided a unique opportunity to study the pathogenesis of measles immune suppression in unvaccinated children. In peripheral blood mononuclear cells (PBMC) of prodromal measles patients, we detected MV-infected memory CD4⁺ and CD8⁺ T cells and naive and memory B cells at similar levels as those observed in NHPs. In paired PBMC collected before and after measles we found reduced frequencies of circulating memory B cells and increased frequencies of r

SUBMITTER: Laksono BM 

PROVIDER: S-EPMC6251901 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature