Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System.

ABSTRACT: Diabetes mellitus is a disease caused by innate or acquired insulin deficiency, resulting in altered glucose metabolism and high blood glucose levels. Chronic hyperglycemia is linked to development of several ocular pathologies affecting the anterior segment, including diabetic corneal neuropathy and keratopathy, neovascular glaucoma, edema, and cataracts leading to significant visual defects. Due to increasing disease prevalence, related medical care costs, and visual impairment resulting from diabetes, a need has arisen to devise alternative systems to study molecular mechanisms involved in disease onset and progression. In our current study, we applied a novel 3D in vitro model of the human cornea comprising of epithelial, stromal, and neuronal components cultured in silk scaffolds to s

SUBMITTER: Deardorff PM 

PROVIDER: S-EPMC6251923 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature