Status of TMPRSS2-ERG fusion in prostate cancer patients from India: correlation with clinico-pathological details and TMPRSS2 Met160Val polymorphism.

ABSTRACT:

Background

Prostate cancer (PCa) shows considerable clinical heterogeneity that has been primarily attributed to variable molecular alterations. TMPRSS2-ERG fusion is one such molecular subtype that has been associated with predominantly poor prognosis. More recently, a single nucleotide polymorphism (SNP) in the TMPRSS2 gene rs12329760 C>T (Met160Val) has been shown to positively correlate with the fusion status and also to be associated with increased risk for PCa. The aim of the present study is to determine the frequency of TMPRSS2-ERG fusion and association of rs12329760 in Indian PCa patients with fusion status.

Methods

TMPRSS2-ERG fusion by fluorescence in situ hybridization was determined in 102 of 150 PCa biops

SUBMITTER: Bhanushali A 

PROVIDER: S-EPMC6251948 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature