Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry.

ABSTRACT: Biomimetic liposomes have a wide array of applications in several areas, ranging from medicinal chemistry to synthetic biology. Due to their biocompatibility and biological relevance, there is particular interest in the formation of synthetic phospholipid vesicles and the development of methods to tune their properties in a controlled manner. However, while true biological membranes are capable of responding to environmental stimuli by enzymatically remodeling their composition, synthetic liposomes are typically static once formed. Herein we report the chemoselective reaction of the natural amine-containing lysosphingomyelin with a series of long-chain aldehydes to form imines. This transformation results in the formation of phospholipid liposomes that are in dynamic equilibrium with the a

SUBMITTER: Seoane A 

PROVIDER: S-EPMC6251970 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature