Cell Cycle Heterogeneity Can Generate Robust Cell Type Proportioning.

ABSTRACT: Cell-cell heterogeneity can facilitate lineage choice during embryonic development because it primes cells to respond to differentiation cues. However, remarkably little is known about the origin of heterogeneity or whether intrinsic and extrinsic variation can be controlled to generate reproducible cell type proportioning seen in vivo. Here, we use experimentation and modeling in D. discoideum to demonstrate that population-level cell cycle heterogeneity can be optimized to generate robust cell fate proportioning. First, cell cycle position is quantitatively linked to responsiveness to differentiation-inducing signals. Second, intrinsic variation in cell cycle length ensures cells are randomly distributed throughout the cell cycle at the onset of multicellular development. Finally, extrin

SUBMITTER: Gruenheit N 

PROVIDER: S-EPMC6251973 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature