Aequatus: an open-source homology browser.

ABSTRACT:

Background

Phylogenetic information inferred from the study of homologous genes helps us to understand the evolution of genes and gene families, including the identification of ancestral gene duplication events as well as regions under positive or purifying selection within lineages. Gene family and orthogroup characterization enables the identification of syntenic blocks, which can then be visualized with various tools. Unfortunately, currently available tools display only an overview of syntenic regions as a whole, limited to the gene level, and none provide further details about structural changes within genes, such as the conservation of ancestral exon boundaries amongst multiple genomes.

Findings

We present Aequatus, an open-source web-based tool that provides an in-dep

SUBMITTER: Thanki AS 

PROVIDER: S-EPMC6251984 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature