A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine.

ABSTRACT: Patient-derived xenograft (PDX) models are increasingly being used in oncology drug development because they offer greater predictive value than traditional cell line models. Using novel tools to critique model validity and reliability we performed a systematic review to identify all original publications describing the derivation of PDX models of colon, prostate, breast and lung cancer. Validity was defined as the ability to recapitulate the disease of interest. The study protocol was registered with the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES). Searches were performed in Embase, MEDLINE and Pubmed up to July 2017. A narrative data synthesis was performed. We identified 105 studies of model validations; 29 for breast, 29 for c

SUBMITTER: Collins AT 

PROVIDER: S-EPMC6252062 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature