Preliminary evaluation of a novel ¹⁸F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer.

ABSTRACT:

Introduction

Poly (ADP-ribose) polymerase-1 (PARP-1) plays many roles in prostate cancer (PC), such as mediating DNA damage repair, transcriptional regulation and nuclear hormone receptor signaling. Because of this, PARP-1 has been targeted for therapy in PC, and non-invasive imaging of PARP-1 could help predict which patients are likely to respond to such therapy. Several PARP-1 positron emission tomography (PET) imaging agents have been developed and show promise for imaging PARP-1 expression in breast, brain, and lung cancer in small animals, but not as yet in prostate cancer. [¹⁸F]WC-DZ-F is an analogue of [¹⁸F]FluorThanatrace (FTT) and [¹²⁵I]KX1, which are well-established PARP-1 ligands for measuring PARP-1 expression. Herein, we evaluated the

SUBMITTER: Zhou D 

PROVIDER: S-EPMC6252111 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature