Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies.

ABSTRACT: The anterior commissure (AC) is a phylogenetically conserved inter-hemispheric connection found among vertebrates with bilateral symmetry. The AC connects predominantly olfactory areas but many aspects of its development and structure are unknown. To fill this gap, we investigated the embryonic and postnatal development of the AC by tracing axons with DiI and the piggyback transposon multicolor system. With this strategy, we show that axon growth during establishment of the AC follows a strictly regulated timeline of events that include waiting periods ("regressive strategies") as well as periods of active axon outgrowth ("progressive strategies"). We also provide evidence that these processes may be regulated in the midline via overexpression of chondroitin sulfate proteoglycans. Addition

SUBMITTER: Martin-Lopez E 

PROVIDER: S-EPMC6252112 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature