Development of leptin resistance in sucrose drinking rats is associated with consuming carbohydrate-containing solutions and not calorie-free sweet solution.

ABSTRACT: Rats offered 30% sucrose solution plus chow or a sucrose-free diet develop leptin resistance within 4 weeks. This experiment tested whether leptin resistance was associated with the reward of sweet taste or the pre- or post-absorptive effects of consumption of simple carbohydrate. Male Sprague Dawley rats were offered a sucrose-free diet (NS), a diet containing 67% calories as sucrose (HS) or NS diet plus 30% sucrose (LS), 0.03% saccharin (Sacc) or 20% SolCarb^® solution for 38 days. SolCarb^® is a maltodextrin powder. Sacc rats initially drank more than LS rats, but intakes were the same after Day 20. SolCarb^® and LS rats drank the same number of calories from Day 15 to the end of the experiment. SolCarb^® and LS rats ate less dry food than other g

SUBMITTER: Harris RBS 

PROVIDER: S-EPMC6252119 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature