Reversible secretome and signaling defects in diabetic mesenchymal stem cells from peripheral arterial disease patients.

ABSTRACT:

Objective

Regenerative medicine seeks to stall or to reverse the pathologic consequences of chronic diseases. Many people with diabetes have peripheral arterial disease (PAD), which increases their already high risk of major amputation. Cellular therapies are a promising regenerative medicine approach to PAD that can be used to focally inject regenerative cells to endangered tissue beds. Mesenchymal stem cells (MSCs) are known to promote tissue regeneration through stromal support and paracrine stimulation of new blood vessels (angiogenesis). Whereas little is known about human diabetic MSCs (dMSCs), particularly those from patients with PAD, dMSCs have a limited expansion capacity but can be improved with human platelet lysate (PL) supplementation. PL is rich in many growth factor

SUBMITTER: Chadid T 

PROVIDER: S-EPMC6252140 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature